Most diseases are the consequence of the breakdown of cellular processes, but the
relationships among genetic/epigenetic defects, the molecular interaction networks …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

Complex diseases are caused by perturbations of biological networks. Genetic analysis
approaches focused on individual genetic determinants are unlikely to characterize the …

Metabolism is a vital cellular process, and its malfunction is a major contributor to human
disease. Metabolic networks are complex and highly interconnected, and thus systems-level …

Background Scientists have been trying to understand the molecular mechanisms of
diseases to design preventive and therapeutic strategies for a long time. For some diseases …

The use of networks to integrate different genetic, proteomic, and metabolic datasets has
been proposed as a viable path toward elucidating the origins of specific diseases. Here we …

Bordbar A, Palsson BO (University of California San Diego, La Jolla, CA, USA). Using the
reconstructed genome‐scale human metabolic network to study physiology and pathology …

A better understanding of human metabolism and its relationship with diseases is an
important task in human systems biology studies. In this paper, we present a high‐quality …

Increasing amounts of sequence data are becoming available for a wide range of non-
model organisms. Investigating and modelling the metabolic behaviour of those organisms …

Genes carrying mutations associated with genetic diseases are present in all human cells;
yet, clinical manifestations of genetic diseases are usually highly tissue-specific. Although …