The stria vascularis is a nonsensory structure that is essential for auditory hair cell function
by maintaining potassium concentration of the scala media. During mouse embryonic …

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET
receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound …

A gene causing autosomal-recessive, nonsyndromic hearing loss, DFNB39, was previously
mapped to an 18 Mb interval on chromosome 7q11. 22-q21. 12. We mapped an additional …

The mammalian auditory sensory epithelium, the organ of Corti, is a highly ordered cellular
structure that comprises two types of auditory hair cells and several types of nonsensory …

Mechanosensory hair cells (HCs) residing in the inner ear are critical for hearing and
balance. Precise coordination of proliferation, sensory specification, and differentiation …

A variety of different signaling pathways are necessary for development and maintenance of
the human auditory system. Normal hearing allows for the detection of soft sounds within the …

Abstract Objectives/Hypothesis: To examine the effect of hepatocyte growth factor (HGF) for
protection of auditory hair cells against aminoglycosides and its molecular mechanisms …

Deletion of fibroblast growth factor receptor 3 (Fgfr3) leads to hearing impairment in mice
due to defects in the development of the organ of Corti, the sensory epithelium of the …

Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET
cellular proto-oncogene, are expressed in the nervous system from pre-natal development …

Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower
vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is …