Analysis of lung adenocarcinoma subtypes based on immune signatures identifies clinical implications for cancer therapy

F Xu, J Chen, X Yang, X Hong, Z Li, L Lin… - Molecular Therapy …, 2020 - cell.com
Lung cancer is the most common cause of cancer deaths worldwide, and lung
adenocarcinoma (LUAD) is the most common histological subtype. However, the prognostic …

Development and validation of an immune‐related prognostic signature in lung adenocarcinoma

S Sun, W Guo, Z Wang, X Wang, G Zhang… - Cancer …, 2020 - Wiley Online Library
Background Lung adenocarcinomas (LUAD) is the most common histological subtype of
lung cancers. Tumor immune microenvironment (TIME) is involved in tumorigeneses …

Tumor microenvironment characterization identifies two lung adenocarcinoma subtypes with specific immune and metabolic state

J Huang, J Li, S Zheng, Z Lu, Y Che, S Mao… - Cancer …, 2020 - Wiley Online Library
The tumor microenvironment (TME) is a vital component of tumor tissue. Increasing
evidence suggests their significance in predicting outcomes and guiding therapies …

Epigenome signature as an immunophenotype indicator prompts durable clinical immunotherapy benefits in lung adenocarcinoma

X Pan, C Zhang, J Wang, P Wang, Y Gao… - Briefings in …, 2022 - academic.oup.com
Intertumoral immune heterogeneity is a critical reason for distinct clinical benefits of
immunotherapy in lung adenocarcinoma (LUAD). Tumor immunophenotype (immune 'Hot'or …

Identification and validation of the immune subtypes of lung adenocarcinoma: implications for immunotherapy

Y Song, S Yan, W Fan, M Zhang, W Liu, H Lu… - Frontiers in Cell and …, 2020 - frontiersin.org
Lung adenocarcinoma (LUAD) is a devastating disease with poor patient survival. Cancer
immunotherapy has revolutionized the treatment of LUAD, but only a limited number of …

[HTML][HTML] Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers

M Chen, X Liu, J Du, XJ Wang, L Xia - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the two
major subtypes of lung cancer, with LUSC exhibits faster progression rate than LUAD. To …

Identification of an immune signature predicting prognosis risk of patients in lung adenocarcinoma

Q Song, J Shang, Z Yang, L Zhang, C Zhang… - Journal of translational …, 2019 - Springer
Background Lung cancer has become the most common cancer type and caused the most
cancer deaths. Lung adenocarcinoma (LUAD) is one of the major type of lung cancer. This …

A prognostic nomogram combining immune-related gene signature and clinical factors predicts survival in patients with lung adenocarcinoma

C Song, Z Guo, D Yu, Y Wang, Q Wang, Z Dong… - Frontiers in …, 2020 - frontiersin.org
The existence of tumor heterogeneity and complex carcinogenic mechanisms in lung
adenocarcinoma (LUAD) make the most commonly used TNM staging system unable to well …

Signatures of multi-omics reveal distinct tumor immune microenvironment contributing to immunotherapy in lung adenocarcinoma

Z Huang, B Li, Y Guo, L Wu, F Kou, L Yang - Frontiers in Immunology, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) contains a variety of genomic and epigenomic
abnormalities; the effective tumor markers related to these abnormalities need to be further …

An immune gene signature to predict prognosis and immunotherapeutic response in lung adenocarcinoma

H Chen, R Lin, W Lin, Q Chen, D Ye, J Li, J Feng… - Scientific Reports, 2022 - nature.com
Lung adenocarcinoma is one of the most common malignant tumors worldwide. The
purpose of this study was to construct a stable immune gene signature for prediction of …