Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

J Yan, W Xu, C Lenahan, L Huang, U Ocak… - Fluids and Barriers of …, 2022 - Springer
Background C–C chemokine receptor type 1 (CCR1) and its endogenous ligand, CCL5,
participate in the pathogenesis of neuroinflammatory diseases. However, much remains …

[HTML][HTML] CCR1 activation promotes neuroinflammation through CCR1/TPR1/ERK1/2 signaling pathway after intracerebral hemorrhage in mice

J Yan, G Zuo, P Sherchan, L Huang, U Ocak, W Xu… - …, 2020 - Elsevier
The activation of CC chemokine receptor type 1 (CCR1) has been shown to be pro-
inflammatory in several animal models of neurological diseases. The objective of this study …

CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice

J Lin, Y Xu, P Guo, YJ Chen, J Zhou, M Xia… - Journal of translational …, 2023 - Springer
Background Owing to metabolic disequilibrium and immune suppression, intracerebral
hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of …

[HTML][HTML] Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice

S Deng, P Sherchan, P Jin, L Huang, Z Travis… - …, 2020 - Elsevier
Hematoma is a crucial factor leading to poor prognosis after intracerebral hemorrhage (ICH).
Promoting microglial phagocytosis to enhance hematoma resolution may be an important …

Chemokine CCL2 contributes to BBB disruption via the p38 MAPK signaling pathway following acute intracerebral hemorrhage

F Guo, D Xu, Y Lin, G Wang, F Wang, Q Gao… - The FASEB …, 2020 - Wiley Online Library
Intracerebral hemorrhage (ICH) remains a devastating type of stroke that lacks an effective
treatment. Recent evidence has demonstrated that CCL2 is involved in the blood‐brain …

Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in …

S Deng, P Jin, P Sherchan, S Liu, Y Cui… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …

The CCL2‐CCR2 system affects the progression and clearance of intracerebral hemorrhage

Y Yao, SE Tsirka - Glia, 2012 - Wiley Online Library
Intracerebral hemorrhage (ICH) has been associated with inflammation and apoptosis. The
CCL2‐CCR2 chemotactic system is one of the major signaling pathways that induce …

Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice

OB Dimitrijevic, SM Stamatovic, RF Keep… - Stroke, 2007 - Am Heart Assoc
Background and Purpose—The chemokine, monocyte chemoattractant protein-1 (CCL2), is
a major factor driving leukocyte infiltration into the brain parenchyma in a variety of …

Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage

Q Tian, Y Li, S Feng, C Liu, Y Guo, G Wang… - International …, 2023 - Elsevier
Background and purpose Neuroinflammation is an important mechanism underlying brain
injury caused by subarachnoid hemorrhage (SAH). CC chemokine receptor type 1 (CCR1) …

CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke

S Zhou, C Liu, J Wang, J Ye, Q Lian… - Journal of Cerebral …, 2024 - journals.sagepub.com
The crosstalk between reactive astrocytes and infiltrated immune cells plays a critical role in
maintaining blood-brain barrier (BBB) integrity. However, how astrocytes interact with …