J Yan, G Zuo, P Sherchan, L Huang, U Ocak, W Xu… - …, 2020 - Elsevier
The activation of CC chemokine receptor type 1 (CCR1) has been shown to be pro- inflammatory in several animal models of neurological diseases. The objective of this study …
J Lin, Y Xu, P Guo, YJ Chen, J Zhou, M Xia… - Journal of translational …, 2023 - Springer
Background Owing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of …
S Deng, P Sherchan, P Jin, L Huang, Z Travis… - …, 2020 - Elsevier
Hematoma is a crucial factor leading to poor prognosis after intracerebral hemorrhage (ICH). Promoting microglial phagocytosis to enhance hematoma resolution may be an important …
F Guo, D Xu, Y Lin, G Wang, F Wang, Q Gao… - The FASEB …, 2020 - Wiley Online Library
Intracerebral hemorrhage (ICH) remains a devastating type of stroke that lacks an effective treatment. Recent evidence has demonstrated that CCL2 is involved in the blood‐brain …
S Deng, P Jin, P Sherchan, S Liu, Y Cui… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …
Intracerebral hemorrhage (ICH) has been associated with inflammation and apoptosis. The CCL2‐CCR2 chemotactic system is one of the major signaling pathways that induce …
OB Dimitrijevic, SM Stamatovic, RF Keep… - Stroke, 2007 - Am Heart Assoc
Background and Purpose—The chemokine, monocyte chemoattractant protein-1 (CCL2), is a major factor driving leukocyte infiltration into the brain parenchyma in a variety of …
Q Tian, Y Li, S Feng, C Liu, Y Guo, G Wang… - International …, 2023 - Elsevier
Background and purpose Neuroinflammation is an important mechanism underlying brain injury caused by subarachnoid hemorrhage (SAH). CC chemokine receptor type 1 (CCR1) …
S Zhou, C Liu, J Wang, J Ye, Q Lian… - Journal of Cerebral …, 2024 - journals.sagepub.com
The crosstalk between reactive astrocytes and infiltrated immune cells plays a critical role in maintaining blood-brain barrier (BBB) integrity. However, how astrocytes interact with …