Induction of cell death represents a primary goal of most anticancer treatments. Despite the
efficacy of such approaches, a small population of “persisters” develop evasion strategies to …

Cancer is a category of diseases involving abnormal cell growth with the potential to invade
other parts of the body. Chemotherapy is the most widely used first-line treatment for multiple …

Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Cancer cell dormancy is a process whereby cells enter reversible cell cycle arrest, termed
quiescence. Quiescence is essential for cancer cells to acquire additional mutations, to …

Immune checkpoint blockade (ICB) therapy has recently shown promise in treating several
malignancies. However, only a limited number of patients respond to this treatment, partially …

The mechanisms that determine whether a tumor cell that has disseminated to a secondary
site will resume growth immediately, die or enter a state of dormancy are poorly understood …

Background and aim Pyroptosis is an inflammatory form of programmed cell death
implicated in inflammation and disease. Moreover, inducing pyroptosis has been …

Purpose: The induced death signals following oncogene inhibition underlie clinical efficacy
of molecular targeted therapies against human cancer, and defects of intact cell apoptosis …

Background Unraveling the mystery of cell death is one of the most fundamental progresses
of life sciences during the past decades. Regulated cell death (RCD) or programmed cell …

The tumor immune microenvironment (TIME) plays a key role in immunosuppression in
cancer, which results in tumorigenesis and tumor progression, and contributes to …