[HTML][HTML] Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
FS Oladunni, JG Park, PA Pino, O Gonzalez… - Nature …, 2020 - nature.com
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …
would benefit from validated small animal models. Here, we show that transgenic mice …
SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …
[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …
[PDF][PDF] Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2
RD Jiang, MQ Liu, Y Chen, C Shan, YW Zhou… - Cell, 2020 - cell.com
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We
previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV …
previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV …
[HTML][HTML] SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …
[PDF][PDF] A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …
with millions of human infections. One limitation to the evaluation of potential therapies and …
Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …
[HTML][HTML] K18-hACE2 mice develop respiratory disease resembling severe COVID-19
SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic.
Several animal models have been rapidly developed that recapitulate the asymptomatic to …
Several animal models have been rapidly developed that recapitulate the asymptomatic to …
[HTML][HTML] COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice
C Lutz, L Maher, C Lee, W Kang - Human Genomics, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all
over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 …
over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 …
The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …