KLF transcription factors in bone diseases

H Wang, J Han, G Dmitrii, K Ning… - Journal of Cellular and …, 2024 - Wiley Online Library
Krüppel‐like factors (KLFs) are crucial in the development of bone disease. They are a
family of zinc finger transcription factors that are unusual in containing three highly …

Krüppel-like factors in bone biology

S Zakeri, H Aminian, S Sadeghi… - Cellular signalling, 2022 - Elsevier
The krüppel-like factor (KLF) family is a group of zinc finger transcription factors and
contributes to different cellular processes such as differentiation, proliferation, migration, and …

Kruppel-like factors in skeletal physiology and pathologies

M Abe, N Saeki, Y Ikeda, S Ohba - International Journal of Molecular …, 2022 - mdpi.com
Kruppel-like factors (KLFs) belong to a large group of zinc finger-containing transcription
factors with amino acid sequences resembling the Drosophila gap gene Krüppel. Since the …

[HTML][HTML] The role of KLF transcription factor in the regulation of cancer progression

ZY Li, YX Zhu, JR Chen, X Chang, ZZ Xie - Biomedicine & …, 2023 - Elsevier
Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been
found to play an essential role in the development of various human tissues, including …

Transcriptional regulation of osteoclastogenesis: the emerging role of KLF2

D Rolph, H Das - Frontiers in immunology, 2020 - frontiersin.org
Dysregulation of osteoclastic differentiation and its activity is a hallmark of various
musculoskeletal disease states. In this review, the complex molecular factors underlying …

[HTML][HTML] KLF2 regulates osteoblast differentiation by targeting of Runx2

Z Hou, Z Wang, Y Tao, J Bai, B Yu, J Shen, H Sun… - Laboratory …, 2019 - Elsevier
Osteoblast differentiation plays a critical role in bone formation and maintaining balance in
bone remodeling. Runt-related transcription factor 2 (Runx2) is a central transcription factor …

Krüppel-like factor 4 regulates membranous and endochondral ossification

I Michikami, T Fukushi, M Tanaka, H Egusa… - Experimental cell …, 2012 - Elsevier
Krüppel-like factor 4 (KLF4/GKLF/EZF) is a zinc finger type of transcription factor highly
expressed in the skin, intestine, testis, lung and bone. The role played by Klf4 has been …

[HTML][HTML] The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation

I Kim, JH Kim, K Kim, S Seong, N Kim - BMB reports, 2019 - ncbi.nlm.nih.gov
Abstract Kruppel-like factor 2 (KLF2) has been implicated in the regulation of cell
proliferation, differentiation, and survival in a variety of cells. Recently, it has been reported …

[HTML][HTML] Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts

JH Kim, K Kim, BU Youn, J Lee, I Kim… - The Journal of cell …, 2014 - ncbi.nlm.nih.gov
Osteoblasts not only control bone formation but also support osteoclast differentiation. Here
we show the involvement of Kruppel-like factor 4 (KLF4) in the differentiation of osteoclasts …

Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …