An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
W Du, DL Hurdiss, D Drabek, AZ Mykytyn… - Science …, 2022 - science.org
The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which
displays notable immune escape potential through mutations at key antigenic sites on the …
displays notable immune escape potential through mutations at key antigenic sites on the …
Omicron: Master of immune evasion maintains robust ACE2 binding
M Hoffmann, L Zhang, S Pöhlmann - Signal Transduction and Targeted …, 2022 - nature.com
The spike (S) protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of
these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A …
these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A …
Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …
spread quickly around the world due to its enhanced transmissibility. The variant became …
Evolution of immune evasion and host range expansion by the SARS-CoV-2 B. 1.1. 529 (Omicron) variant
W Ren, Y Zhang, J Rao, Z Wang, J Lan, K Liu, X Zhang… - MBio, 2023 - Am Soc Microbiol
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B. 1.1.
529 (Omicron) has rapidly become the dominant strain, with an unprecedented number of …
529 (Omicron) has rapidly become the dominant strain, with an unprecedented number of …
Structures of Omicron spike complexes and implications for neutralizing antibody development
H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …
worldwide. The high number of spike mutations is responsible for the broad immune evasion …
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
such as the Omicron variants that are highly transmissible and immune evasive …
such as the Omicron variants that are highly transmissible and immune evasive …
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination
X Chi, Y Guo, G Zhang, H Sun, J Zhang, M Li… - Signal transduction and …, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by
infection-and vaccination-induced antibodies, highlighting the demands for research on the …
infection-and vaccination-induced antibodies, highlighting the demands for research on the …
[HTML][HTML] SARS-CoV-2 Omicron-B. 1.1. 529 leads to widespread escape from neutralizing antibody responses
On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …
529 was announced, containing far more mutations in Spike (S) than previously reported …
Evidence for an ACE2-independent entry pathway that can protect from neutralization by an antibody used for COVID-19 therapy
M Hoffmann, A Sidarovich, P Arora, N Krüger… - MBio, 2022 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 variants of concern (VOC) acquired mutations in the spike (S)
protein, including E484K, that confer resistance to neutralizing antibodies. However, it is …
protein, including E484K, that confer resistance to neutralizing antibodies. However, it is …