Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

Lung innate immunity is the first line of defence against inhaled allergens, pathogens and
environmental pollutants. Cellular metabolism plays a key role in innate immunity. Catabolic …

Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple
organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of …

Innate and adaptive immunity participate in and regulate numerous human diseases.
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …

During sepsis, the importance of alterations in cell metabolism is underappreciated. The
cellular metabolism, which has a variable metabolic profile in different cells and disease …

Lung macrophages constitute the first line of defense against airborne particles and
microbes and are key to maintaining pulmonary immune homeostasis. There is increasing …

A growing number of findings highlight the crucial role of metabolic reprogramming in
macrophage activation. Metabolic pathways are closely interconnected and recent literature …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

Metabolic reprogramming of innate immune cells occurs during both the hyperinflammatory
and immunotolerant phases of sepsis. The hypoxia inducible factor (HIF) signaling pathway …