Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

The small GTPases of the Ras superfamily mediate numerous biological processes through
their ability to cycle between an inactive GDP-bound and an active GTP-bound form. Among …

Members of a family of intracellular molecular switches, the small GTPases, sense
modifications of the extracellular environment and transduce them into a variety of …

Small GTPases are a family of GDP‐/GTP‐binding proteins that serve as biomolecular
switches inside cells to control a variety of essential cellular processes. Aberrant function …

Approximately 2% of genes predicted by the sequenced human genome encode small
GTPases and their regulators, highlighting the biological significance of regulated GTPase …

Heterotrimeric GPCRs (G-protein-coupled receptors) form the largest group of integral
membrane receptor proteins and mediate diverse physiological processes. In addition to …

▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Small GTP-binding proteins related to ras regulate many basic processes in all eukaryotes
(Hall, 1990). p21'** is an essential component of receptor-mediated signal transduction …

The Ras superfamily of small GTPases is composed of more than 150 members, which
share a conserved structure and biochemical properties, acting as binary molecular …