Placental insufficiency is associated with reduced oxygen and nutrient supply to the fetus,
which may result in fetal growth restriction (FGR). In an attempt to cope with the hostile …

Placental insufficiency is a process leading to progressive deterioration in placental function
and a decrease in transplacental transfer of oxygen and nutrients to the fetus. The resulting …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Hemochorial placentation is orchestrated through highly regulated temporal and spatial
decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell …

Fetal growth restriction is most commonly caused by failure of the placenta to meet the
increasing demands for oxygen and substrate of the developing fetus, resulting in common …

Fetal programming occurs when the normal pattern of fetal development is disrupted by an
abnormal stimulus or 'insult'applied at a critical point in in utero development. This then …

Severe fetal growth restriction (FGR) is often associated with hypoxia. We studied FGR
hypoxia in an experimental model which is produced by exposing pregnant ewes to a …

The developing fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …

Key points Exposure of pregnant mice to chronic hypoxia at 13% O2 induces fetal growth
restriction but increases placental weight. Sex dimorphism induces differential responses in …

Intrauterine hypoxia is a significant clinical challenge in obstetrics that affects both the
pregnant mother and fetus. Intrauterine hypoxia can occur in pregnant women living at high …