Background: The emergence of carbapenem-hydrolyzing metallo-β-lactamases (MBLs) is a
serious threat to clinical medication of carbapenems. We evaluated the contributions of IMP …

Rapid and reliable detection of carbapenem-resistant bacteria is an important infection-
control measure and a crucial aspect of antimicrobial chemotherapy. IMP-type metallo-β …

Introduction Multidrug resistant microorganisms are a serious threat to human health. Under
the circumstances, a front line of antimicrobials in clinical setting may be carbapenem β …

Objectives The objective of this study was to characterize a novel IMP-type metallo-β-
lactamase (MBL) found in an MDR clinical isolate of Pseudomonas aeruginosa. Methods …

Carbapenem resistance in clinical isolates of P. aeruginosa has risen notably in recent
years. P. aeruginosa has different mechanisms for carbapenem resistance, such as …

Limited β-lactams show antipseudomonal activity. The rapid spread of IMP-type metallo-β-
lactamases (MBLs), which have a broad spectrum of substrates and a poor susceptibility to …

Acquired metallo-β-lactamases (MBLs) are the most common acquired carbapenemases in
Pseudomonas aeruginosa. They confer a broad-spectrum β-lactam resistance profile …

The acquisition of metallo-b-lactamases (MBLs) is one of the most important emerging
mechanisms of carbapenem resistance in Pseudomonas aeruginosa. Four families of …

Background Pseudomonas aeruginosa is considered as one of the most emerging threats in
this century. Serious infections caused by this pathogen are often treated by carbapenems …

Background: Metallo-β-lactamase is one of the feared resistance mechanisms in
Pseudomonas aeruginosa. Methods: β-Lactamase activity was determined using crude …