Metastases are the leading cause of mortality in patients with cancer. Metastasis formation
requires cancer cells to adapt their cellular phenotype. However, how metabolism supports …

Metabolic reprogramming is a hallmark of cellular transformation, yet little is known about
metabolic changes that accompany tumor metastasis. Here we show that primary breast …

Proline is a readily released stress substrate that can be metabolized by proline oxidase
(POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

The extracellular matrix is a major component of the local environment—that is, the niche—
that determines cell behaviour. During metastatic growth, cancer cells shape the …

Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is
the only proteogenic secondary amino acid that is abundant in the body. Recent studies …

Dysregulated metabolism contributes to cancer initiation and progression, but the key
drivers of these pathways are just being discovered. Here, we report a critical role for proline …

Significance: It is increasingly clear that proline metabolism plays an important role in
metabolic reprogramming, not only in cancer but also in related fields such as aging …

Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal
organs persist, but the precise mechanisms that facilitate metabolic adaptations remain …

Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes.
Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork …