Silymarin impacts on immune system as an immunomodulator: One key for many locks

N Esmaeil, SB Anaraki, M Gharagozloo… - International …, 2017 - Elsevier
Silymarin is a flavonoid complex extracted from the Silybum marianum plant. It acts as a
strong antioxidant and free radical scavenger by different mechanisms. But in addition to …

Immunosuppressive effect of silymarin on mitogen‐activated protein kinase signalling pathway: The impact on T cell proliferation and cytokine production

M Gharagozloo, S Jafari, N Esmaeil… - Basic & clinical …, 2013 - Wiley Online Library
Silymarin, a polyphenolic flavonoid derived from milk thistle (Silybum marianum), is known
to have anti‐inflammatory, hepatoprotective and anticarcinogenic effects. In this study, the in …

Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-κB activity and IL-2 production

M Gharagozloo, E Velardi, S Bruscoli, M Agostini… - Pharmacological …, 2010 - Elsevier
Silymarin, a mixture of bioactive flavonolignans isolated from Silybum marianum, exhibits
anti-carcinogenic, anti-inflammatory and cytoprotective effects. In this study, the in vitro …

Silymarin: a review on paving the way towards promising pharmacological agent

MN Akhtar, R Saeed, F Saeed, A Asghar… - … Journal of Food …, 2023 - Taylor & Francis
Advancements in the field of research and development have paved toward the use of
herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one …

Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase

OP Gupta, S Sing, S Bani, N Sharma, S Malhotra… - Phytomedicine, 2000 - Elsevier
Silymarin, a mixture of flavonolignans, comprised mainly of three isomers, silybin, silydianin
and silychristin isolated from the fruits of Silybum marianum, is currently in therapeutic use …

Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications

X Wang, Z Zhang, SC Wu - Journal of agricultural and food …, 2020 - ACS Publications
Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Silymarin: Not just another antioxidant

FC Camini, DC Costa - Journal of basic and clinical physiology and …, 2020 - degruyter.com
Abstract Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract
that has been used for many centuries to treat liver diseases. In recent years, several studies …

The use of silymarin in the treatment of liver diseases

R Saller, R Meier, R Brignoli - Drugs, 2001 - Springer
The high prevalence of liver diseases such as chronic hepatitis and cirrhosis underscores
the need for efficient and cost-effective treatments. The potential benefit of silymarin …

[PDF][PDF] Dose-dependent anti-inflammatory effect of silymarin in experimental animal model of chronic inflammation

R Hussain - African journal of Pharmacy and Pharmacology, 2009 - researchgate.net
Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) that has
antiinflammatory, cytoprotective, and anticarcinogenic effects. It has been used medicinally …

[HTML][HTML] Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

M Koushki, RF Yekta, N Amiri-Dashatan - Journal of Functional Foods, 2023 - Elsevier
Cancer is identified as second leading causes of death and imposes a significant
psychological and economic burden on societies. Due to its high prevalence, and a main …