Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

NK cells are cytotoxic lymphocytes important in defense against viral infection and cancer.
NK cells mediate cytotoxicity predominantly through directed secretion of lytic granules …

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are
indispensable for NK-cell cytotoxicity because their release results in the induction of target …

NK cells are renowned for their ability to kill virally infected or transformed host cells by
release of cytotoxic granules containing granzymes and perforin. NK cells also have …

The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors
has been difficult to assess. Using Drosophila insect cells, which express ligands of human …

Cytotoxic lymphocytes, encompassing cytotoxic T lymphocytes (CTLs) and natural killer (NK)
cells, kill pathogen-infected, neoplastic, or certain hematopoietic cells through the release of …

Natural killer (NK) cells are innate effector lymphocytes necessary for defence against
stressed, microbe-infected, or malignant cells. NK cells kill target cells by either of two major …

Natural killer (NK) cell cytotoxicity involves the formation of an activating immunological
synapse (IS) between the effector and target cell through which granzymes and perforin …

Natural killer (NK) cells target and kill aberrant cells, such as virally infected and tumorigenic
cells. Killing is mediated by cytotoxic molecules which are stored within secretory …

The major mechanism by which natural killer (NK) cells and cytotoxic lymphocytes (CTLs)
kill their targets is regulated exocytosis of specialized granules, termed lytic granules …