Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics
J Liley, C Wallace - PLoS genetics, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have been successful in identifying single
nucleotide polymorphisms (SNPs) associated with many traits and diseases. However, at …
nucleotide polymorphisms (SNPs) associated with many traits and diseases. However, at …
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs
Recent results indicate that genome-wide association studies (GWAS) have the potential to
explain much of the heritability of common complex phenotypes, but methods are lacking to …
explain much of the heritability of common complex phenotypes, but methods are lacking to …
Genomewide association studies: history, rationale, and prospects for psychiatric disorders
Psychiatric GWAS Consortium … - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …
Genome-wide association studies: hypothesis-“free” or “engaged”?
GD Kitsios, E Zintzaras - Translational Research, 2009 - Elsevier
The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …
conceptual framework in the search for variants underlying common disorders: a massive …
False discovery rate control in genome-wide association studies with population structure
We present a comprehensive statistical framework to analyze data from genome-wide
association studies of polygenic traits, producing interpretable findings while controlling the …
association studies of polygenic traits, producing interpretable findings while controlling the …
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
Several lines of evidence suggest that genome-wide association studies (GWAS) have the
potential to explain more of the “missing heritability” of common complex phenotypes …
potential to explain more of the “missing heritability” of common complex phenotypes …
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Genome-wide association studies (GWAS) have identified thousands of variants associated
with complex traits, but their biological interpretation often remains unclear. Most of these …
with complex traits, but their biological interpretation often remains unclear. Most of these …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …