Global analyses of the effect of different cellular contexts on microRNA targeting
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
Tiny giants of gene regulation: experimental strategies for microRNA functional studies
BR Steinkraus, M Toegel… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
The discovery over two decades ago of short regulatory microRNAs (miRNAs) has led to the
inception of a vast biomedical research field dedicated to understanding these powerful …
inception of a vast biomedical research field dedicated to understanding these powerful …
MicroRNA targeting specificity in mammals: determinants beyond seed pairing
Mammalian microRNAs (miRNAs) pair to 3′ UTRs of mRNAs to direct their
posttranscriptional repression. Important for target recognition are∼ 7 nt sites that match the …
posttranscriptional repression. Important for target recognition are∼ 7 nt sites that match the …
microRNA control of cell-cell signaling during development and disease
JW Hagen, EC Lai - Cell Cycle, 2008 - Taylor & Francis
MicroRNAs (miRNAs) are critical post-transcriptional regulators that may collectively control
a majority of animal genes. With thousands of miRNAs identified, a pressing challenge is …
a majority of animal genes. With thousands of miRNAs identified, a pressing challenge is …
Predicting microRNA targeting efficacy in Drosophila
Background MicroRNAs (miRNAs) are short regulatory RNAs that derive from hairpin
precursors. Important for understanding the functional roles of miRNAs is the ability to …
precursors. Important for understanding the functional roles of miRNAs is the ability to …
MicroRNAs: from mechanism to organism
PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3′ UTR evolution
MicroRNAs are small noncoding RNAs that serve as posttranscriptional regulators of gene
expression in higher eukaryotes. Their widespread and important role in animals is …
expression in higher eukaryotes. Their widespread and important role in animals is …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
Widespread regulatory activity of vertebrate microRNA* species
An obligate intermediate during microRNA (miRNA) biogenesis is an∼ 22-nucleotide RNA
duplex, from which the mature miRNA is preferentially incorporated into a silencing complex …
duplex, from which the mature miRNA is preferentially incorporated into a silencing complex …
Coherent but overlapping expression of microRNAs and their targets during vertebrate development
A Shkumatava, A Stark, H Sive… - Genes & …, 2009 - genesdev.cshlp.org
MicroRNAs (miRNAs) are small noncoding RNAs that direct post-transcriptional repression
of protein-coding genes. In vertebrates, each highly conserved miRNA typically regulates …
of protein-coding genes. In vertebrates, each highly conserved miRNA typically regulates …