Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Cellular senescence is implicated in a wide range of physiological and pathological
conditions throughout an organism's entire lifetime. In particular, it has become evident that …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

To identify new genetic regulators of cellular aging and senescence, we performed genome‐
wide comparative RNA profiling with selected human cellular model systems, reflecting …