Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …

Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …

Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

Synaptic dysfunction and failure are processes that occur early in Alzheimer disease (AD)
and are important targets for protective treatments to slow AD progression and preserve …

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
worldwide. One pathological feature of progressing AD is the loss of synapses. This is the …

Synapses have been known for many years to be the crucial target of pathology in different
forms of dementia, in particular Alzheimer's disease (AD). Synapses and their appropriate …

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is
characterized by the accumulation of insoluble aggregates of Aβ-peptides that are …

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …