Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are
indispensable for damage control and tissue remodeling on myocardial injury and principal …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …

▪ Abstract Cardiac fibroblasts play a central role in the maintenance of extracellular matrix in
the normal heart and as mediators of inflammatory and fibrotic myocardial remodeling in the …

Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise
approximately two-thirds of the total number of cardiac cell types. During development …

In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

Cardiac fibroblasts are a major cell population of the heart and are characterized by their
capacity to produce extracellular matrix (ECM). In hearts subjected to pressure overload …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …