Background Pre-implantation embryos exhibit sexual dimorphisms in both primates and
rodents. To determine whether these differences reflected sex-biased expression patterns …

Background Expression patterns between males and females vary in every adult tissue,
even in organs with no conspicuous dimorphisms such as the heart. While studies of male …

The factors limiting the rather inefficient derivation of human embryonic stem cells (HESCs)
are not fully understood. The aim of this study was to analyze the sex ratio in our 42 …

Background As sex determines mammalian development, understanding the nature and
developmental dynamics of the sexually dimorphic transcriptome is important. To explore …

Sex‐specific transcriptional and epigenomic profiles are detectable in the embryo very soon
after fertilization. I propose that in male (XY) and female (XX) pre‐implantation embryos sex …

The divergence of distinct cell populations from multipotent progenitors is poorly understood,
particularly in vivo. The gonad is an ideal place to study this process, because it originates …

In adult tissues, sexual dimorphism is largely attributed to sex hormone effects, although
there is increasing evidence for a major role of sex chromosome dosage. During …

Cis-regulatory elements are critical for the precise spatiotemporal regulation of genes during
development. However, identifying functional regulatory sites that drive cell differentiation in …

Several animal and human studies have demonstrated that sex affects kinetics and
metabolism during early embryo development. However, the mechanism governing these …

In mice, primordial germ cells migrate into the genital ridges by embryonic day 13.5 (E13. 5),
where they are then subjected to a sex-specific fate with female and male primordial germ …