MAIT cell activation augments adenovirus vector vaccine immunogenicity
Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment
early immune responses and contribute to protection. We hypothesized that MAIT cells may …
early immune responses and contribute to protection. We hypothesized that MAIT cells may …
MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity
Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …
MAIT cells are activated during human viral infections
B Van Wilgenburg, I Scherwitzl, EC Hutchinson… - Nature …, 2016 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit
potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory …
potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory …
A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa
O Jensen, S Trivedi, JD Meier, KC Fairfax, JS Hale… - Science …, 2022 - science.org
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in
protection against bacterial pathogens at mucosal surfaces through the release of …
protection against bacterial pathogens at mucosal surfaces through the release of …
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
MAIT cells contribute to protection against lethal influenza infection in vivo
B van Wilgenburg, L Loh, Z Chen, TJ Pediongco… - Nature …, 2018 - nature.com
Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like
lymphocytes which are abundant in human lungs and can contribute to protection against …
lymphocytes which are abundant in human lungs and can contribute to protection against …
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
LJ Howson, G Napolitani, D Shepherd… - Nature …, 2018 - nature.com
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-
derived metabolites presented on MR1. Here we show, using a controlled infection of …
derived metabolites presented on MR1. Here we show, using a controlled infection of …
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a
physiologically relevant model of human immunity, are handicapped due to a lack of …
physiologically relevant model of human immunity, are handicapped due to a lack of …
A conserved transcriptional program for MAIT cells across mammalian evolution
H Bugaut, Y El Morr, M Mestdagh, A Darbois… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs,
suggesting important functions. As human and mouse MAIT functional programs appear …
suggesting important functions. As human and mouse MAIT functional programs appear …