Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …

Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …

The past decade has seen the convergence of a series of new insights that arose from
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …

The immune system is now considered a major factor in Alzheimer Disease (AD). This
review seeks to demonstrate how various aspects of the immune system, both in the brain …

Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by a
progressive cognitive decline and dementia. AD brains are marked by amyloid plaques and …

An interaction network exists among cells within the brain, maintaining brain homeostasis
and ensuring its functional plasticity. In addition to neurons, participating cells include …

After years of failed therapeutic attempts targeting beta-amyloid (Aβ) in AD, there is now
increasing evidence suggesting that inflammation holds a pivotal role in AD pathogenesis …

Abstract The Alzheimer's Association's Research roundtable met in April 2015 to explore the
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …