COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab

S Dimai, L Semmler, A Prabhu, H Stachelscheid… - PLoS …, 2021 - journals.plos.org
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-
2 mediated coronavirus disease (COVID19) and mortality is particularly high in these …

Proinflammatory cytokines driving cardiotoxicity in COVID-19

M Colzani, J Bargehr, F Mescia… - Cardiovascular …, 2024 - academic.oup.com
Aims Cardiac involvement is common in patients hospitalized with COVID-19 and correlates
with an adverse disease trajectory. While cardiac injury has been attributed to direct viral …

An immuno-cardiac model for macrophage-mediated inflammation in COVID-19 hearts

L Yang, Y Han, F Jaffre, BE Nilsson-Payant… - Circulation …, 2021 - Am Heart Assoc
Rationale: While respiratory failure is a frequent and clinically significant outcome of
coronavirus disease 2019 (COVID-19), cardiac complications are a common feature in …

[HTML][HTML] Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapy

A Abdi, S AlOtaiby, F Al Badarin, A Khraibi… - Biomedicine & …, 2022 - Elsevier
SARS-CoV-2 causes respiratory illness with a spectrum of systemic complications. However,
the mechanism for cardiac infection and cardiomyocyte injury in COVID-19 patients remains …

[HTML][HTML] Physiology of cardiomyocyte injury in COVID-19

MM Siddiq, AT Chan, L Miorin, AS Yadaw… - Medrxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System shows
that substantial numbers of COVID-19 patients without prior heart disease develop cardiac …

SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19

DJ Clemens, D Ye, W Zhou, CSJ Kim, DR Pease… - Plos one, 2023 - journals.plos.org
Background SARS-CoV-2-mediated COVID-19 may cause sudden cardiac death (SCD).
Factors contributing to this increased risk of potentially fatal arrhythmias include thrombosis …

[HTML][HTML] Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2

L Yang, BE Nilsson-Payant, Y Han, F Jaffré, J Zhu… - Stem cell reports, 2021 - cell.com
Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause of
myocardial histopathology remains unknown. Here, using an established in vivo hamster …

[HTML][HTML] SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

JA Pérez-Bermejo, S Kang, SJ Rockwood… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis
remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed …

What do we know about COVID-19 implications for cardiovascular disease?

Z Wang, M Tang, X Luan… - Frontiers in …, 2023 - frontiersin.org
Public health emergencies caused by Coronavirus-19 (COVID-19) continue to exist across
the globe. Studies have shown that infection with COVID-19 is more severe in people with …

SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

JA Perez-Bermejo, S Kang, SJ Rockwood… - Science translational …, 2021 - science.org
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …