The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Towards improvements for penetrating the blood–brain barrier—recent progress from a material and pharmaceutical perspective
Q He, J Liu, J Liang, X Liu, W Li, Z Liu, Z Ding, D Tuo - Cells, 2018 - mdpi.com
The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the
brain and maintains its bathing microenvironment. However, this barrier is also the obstacle …
brain and maintains its bathing microenvironment. However, this barrier is also the obstacle …
Blood‐brain barrier overview: structural and functional correlation
A Alahmari - Neural plasticity, 2021 - Wiley Online Library
The blood‐brain barrier (BBB) is a semipermeable and extremely selective system in the
central nervous system of most vertebrates, that separates blood from the brain's …
central nervous system of most vertebrates, that separates blood from the brain's …
Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders
The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …
Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
Modulation of the blood–brain barrier for drug delivery to brain
L Han - Pharmaceutics, 2021 - mdpi.com
The blood–brain barrier (BBB) precisely controls brain microenvironment and neural activity
by regulating substance transport into and out of the brain. However, it severely hinders drug …
by regulating substance transport into and out of the brain. However, it severely hinders drug …
Basic physiology of the blood-brain barrier in health and disease: a brief overview
M Kaya, B Ahishali - Tissue Barriers, 2021 - Taylor & Francis
The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …
Medicinal chemistry based approaches and nanotechnology‐based systems to improve CNS drug targeting and delivery
P Vlieghe, M Khrestchatisky - Medicinal research reviews, 2013 - Wiley Online Library
The central nervous system (CNS) is protected by various barriers, which regulate nervous
tissue homeostasis and control the selective and specific uptake, efflux, and metabolism of …
tissue homeostasis and control the selective and specific uptake, efflux, and metabolism of …
Strategies for transporting nanoparticles across the blood–brain barrier
The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology
Introduction: The blood-brain barrier (BBB) is a highly limiting barrier that prevents the brain
from contacting with several circulating molecules, including harmful agents. However …
from contacting with several circulating molecules, including harmful agents. However …