[HTML][HTML] Location-specific signatures of Crohn's disease at a multi-omics scale

CG Gonzalez, RH Mills, Q Zhu, C Sauceda, R Knight… - Microbiome, 2022 - Springer
Background Crohn's disease (CD), an inflammatory bowel disease (IBD) subtype, results
from pathologic interactions between host cells and its resident gut microbes. CD manifests …

[HTML][HTML] Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease

AR Erickson, BL Cantarel, R Lamendella, Y Darzi… - PloS one, 2012 - journals.plos.org
Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although
dysbiosis of the gut microbiota has been implicated in chronic immune-mediated …

[HTML][HTML] Exploring how microbiome signatures change across inflammatory bowel disease conditions and disease locations

GCA Amos, C Sergaki, A Logan, R Iriarte… - Scientific Reports, 2021 - nature.com
Understanding the variables that influence microbiome studies is critical for successful
translational research. Inflammatory bowel disease (IBD) is a complex group of diseases …

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon

L Kong, V Pokatayev, A Lefkovith, GT Carter… - Immunity, 2023 - cell.com
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …

Redefining the IBDs using genome-scale molecular phenotyping

TS Furey, P Sethupathy, SZ Sheikh - Nature reviews Gastroenterology & …, 2019 - nature.com
Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

Anti-inflammatory gut microbial pathways are decreased during Crohn's disease exacerbations

MAY Klaassen, F Imhann, V Collij, J Fu… - Journal of Crohn's …, 2019 - academic.oup.com
Abstract Background and Aims Crohn's disease [CD] is a chronic inflammatory disorder of
the gastrointestinal tract characterised by alternating periods of exacerbation and remission …

Highlighting new phylogenetic specificities of Crohn's disease microbiota

S Mondot, S Kang, JP Furet… - Inflammatory bowel …, 2011 - academic.oup.com
Background Recent studies suggest that gastrointestinal (GI) microbes play a part in the
pathogenesis of Crohn's disease (CD). Methods Fecal samples were collected from 16 …

Distinct microbiotas are associated with ileum-restricted and colon-involving Crohn's disease

T Naftali, L Reshef, A Kovacs, R Porat… - Inflammatory bowel …, 2016 - academic.oup.com
Background The etiology of inflammatory bowel disease is believed to involve a shift in the
microbiota toward more proinflammatory species. Crohn's disease (CD) usually manifests as …

Bacterial protein signals are associated with Crohn's disease

C Juste, DP Kreil, C Beauvallet, A Guillot, S Vaca… - Gut, 2014 - gut.bmj.com
Objective No Crohn's disease (CD) molecular maker has advanced to clinical use, and
independent lines of evidence support a central role of the gut microbial community in CD …

[HTML][HTML] Microbial population differentials between mucosal and submucosal intestinal tissues in advanced Crohn's disease of the ileum

RJ Chiodini, SE Dowd, WM Chamberlin, S Galandiuk… - PloS one, 2015 - journals.plos.org
Since Crohn's disease is a transmural disease, we hypothesized that examination of deep
submucosal tissues directly involved in the inflammatory disease process may provide …