Shared pathogenicity features and sequences between EBV, SARS-coV-2, and HLA class I molecule-binding motifs with a potential role in autoimmunity

Y Adiguzel, N Mahroum, S Muller, M Blank… - Clinical Reviews in …, 2023 - Springer
Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) are extraordinary in their ability to activate autoimmunity as well as to induce diverse …

Immunoinformatics prediction of potential immunodominant epitopes from human coronaviruses and association with autoimmunity

S Mathew, AD Fakhroo, M Smatti, AA Al Thani… - Immunogenetics, 2022 - Springer
Cross-reactivity between different human coronaviruses (HCoVs) might contribute to COVID-
19 outcomes. Here, we aimed to predict conserved peptides among different HCoVs that …

Molecular mimicry, hyperactive immune system, and SARS-COV-2 are three prerequisites of the autoimmune disease triangle following COVID-19 infection

M Vahabi, T Ghazanfari, S Sepehrnia - International Immunopharmacology, 2022 - Elsevier
SARS-CoV-2 infection can produce a variety of clinical manifestations, which are either
directly related to viral tissue damage or indirectly induced by the antiviral immune …

The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis

D Kovačić, J Jotanović, J Laković - Journal of Medical Science, 2021 - jms.ump.edu.pl
Abstract Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute
Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persists as a threat to global health …

[HTML][HTML] On the molecular determinants of the SARS-CoV-2 attack

D Kanduc, Y Shoenfeld - Clinical Immunology (Orlando, Fla.), 2020 - ncbi.nlm.nih.gov
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is linked to a
respiratory syndrome with altered pulmonary and alveolar function that can lead to acute …

Susceptibility and Severity of COVID-19 Are Both Associated With Lower Overall Viral–Peptide Binding Repertoire of HLA Class I Molecules, Especially in Younger …

HRG Basir, MM Majzoobi, S Ebrahimi… - Frontiers in …, 2022 - frontiersin.org
An important number of studies have been conducted on the potential association between
human leukocyte antigen (HLA) genes and COVID-19 susceptibility and severity since the …

From anti-SARS-CoV-2 immune responses to COVID-19 via molecular mimicry

D Kanduc - Antibodies, 2020 - mdpi.com
Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes …

Bioinformatic analysis of B-and T-cell epitopes from SARS-CoV-2 structural proteins and their potential cross-reactivity with emerging variants and other human …

DL Pacheco-Olvera, S Saint Remy-Hernández… - Archives of Medical …, 2022 - Elsevier
Background The mutations in SARS-CoV-2 variants of concern (VOC) facilitate the virus'
escape from the neutralizing antibodies induced by vaccines. However, the protection from …

Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement

M Mohkhedkar, SSK Venigalla, V Janakiraman - Molecular Immunology, 2021 - Elsevier
Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in
COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity …

Molecular Understanding of ACE-2 and HLA-conferred differential susceptibility to COVID-19: host-directed insights opening new windows in COVID-19 Therapeutics

IU Haq, K Krukiewicz, H Tayyab, I Khan… - Journal of Clinical …, 2023 - mdpi.com
The genetic variants of HLAs (human leukocyte antigens) play a crucial role in the virus–
host interaction and pathology of COVID-19. The genetic variants of HLAs not only influence …