Human cytochrome P450 3A4 (CYP3A4) is a major drug-metabolizing enzyme that shows
extreme substrate promiscuity. Moreover, its large and malleable active site can …

Cytochrome P450 (CYP) 3A4 is the most promiscuous of the human CYP enzymes and
contributes to the metabolism of≈ 50% of marketed drugs. It is also the isoform most often …

Cytochrome P450 3A4 (CYP3A4) is a major human drug-metabolizing enzyme, notoriously
known for its extreme substrate promiscuity, allosteric behavior, and implications in drug …

Cytochrome P450 (CYP) enzymes function to catalyze a wide range of reactions, many of
which are critically important for drug response. Members of the human cytochrome P450 3A …

CYP1A2 is one of the major CYPs in human liver (∼ 13%) and metabolises a variety of
clinically important drugs, such as clozapine, lidocaine, theophylline, tacrine, and …

The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than
one-half of marketed drugs. They share high structural and substrate similarity and are often …

Cytochrome P450 3A7 (CYP3A7) is a fetal/neonatal liver enzyme that participates in estriol
synthesis, clearance of all-trans retinoic acid, and xenobiotic metabolism. Compared to the …

Cytochrome P450 3A4 (CYP3A4) catalyzes the initial step in the clearance of many
pharmaceuticals and foreign chemicals. The structurally diverse nature of CYP3A4 …

The CYP2A6 gene spans a region of approximately 6 kb pairs consisting of 9 exons and has
been mapped to the long arm of chromosome 19 (between 19q12 and 19q13. 2). The …

Human cytochrome P450 (CYP) 2A6 and 2A13 play an important role in catalyzing the
metabolism of many environmental chemicals including coumarin, nicotine, and several …