Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

Highlights•The structures of influenza polymerase allow the identification of novel anti-
influenza drugs.•The inhibitors targeting influenza polymerase are discussed.•The screening …

The RNA-dependent RNA polymerase of influenza A virus comprises conserved and
independently-folded subdomains with defined functionalities. The N-terminal domain of the …

The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate
synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L …

The influenza virus is responsible for millions of cases of severe illness annually. Yearly
variance in the effectiveness of vaccination, coupled with emerging drug resistance …

The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric
protein complex responsible for viral RNA transcription and replication, represents a primary …

Antiviral drugs are important in preventing and controlling influenza, particularly when
vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase …

The influenza A polymerase is a heterotrimer which transcribes viral mRNAs and replicates
the viral genome. To initiate synthesis of mRNA, the polymerase binds a host pre-mRNA and …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …