Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …

COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many
cellular processes and are essential for immune cells function. Their activity is controlled by …

SARS-CoV-2 infection can trigger strong inflammatory responses and cause severe lung
damage in COVID-19 patients with critical illness. However, the molecular mechanisms by …

SARS-CoV-2 is the causative agent of the immune response-driven disease COVID-19 for
which new antiviral and anti-inflammatory treatments are urgently needed to reduce …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Severe COVID-19 is associated with hyperinflammation and weak T cell responses against
SARS-CoV-2. However, the links between those processes remain partially characterized …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

The interferon (IFN)–inducible protein Z-DNA binding protein 1 [ZBP1; also known as DNA-
dependent activator of IFN regulatory factors (DAI) and DLM-1] was identified as a double …

COVID-19–associated morbidity and mortality have been attributed to a pathologic host
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …