Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity

AT Ambikan, H Yang, S Krishnan, SS Akusjärvi… - Cell systems, 2022 - cell.com
The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are
heterogeneous, and the progression or fatality of the disease cannot be explained by a …

Metabolic perturbation associated with COVID-19 disease severity and SARS-CoV-2 replication

S Krishnan, H Nordqvist, AT Ambikan, S Gupta… - Molecular & Cellular …, 2021 - ASBMB
Viruses hijack host metabolic pathways for their replicative advantage. In this study, using
patient-derived multiomics data and in vitro infection assays, we aimed to understand the …

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

K Wang, M Khoramjoo, K Srinivasan, PMK Gordon… - Cell Reports …, 2023 - cell.com
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often
associated with debilitating symptoms and adverse multisystem consequences. We obtain …

Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without COVID-19

A D'alessandro, T Thomas, IJ Akpan, JA Reisz… - Cells, 2021 - mdpi.com
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide
challenge. The present large study sought to understand independent and overlapping …

Metabolomic analyses reveal new stage-specific features of COVID-19

H Jia, C Liu, D Li, Q Huang, D Liu… - European …, 2022 - Eur Respiratory Soc
The current pandemic of coronavirus disease 2019 (COVID-19) has affected> 160 million
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

AS Herrera-Van Oostdam, JE Castañeda-Delgado… - PLoS …, 2021 - journals.plos.org
Viral sepsis has been proposed as an accurate term to describe all multisystemic
dysregulations and clinical findings in severe and critically ill COVID-19 patients. The …

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

JW Lee, Y Su, P Baloni, D Chen… - Nature …, 2022 - nature.com
A better understanding of the metabolic alterations in immune cells during severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity …

Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19

LG Gardinassi, CP Servian, GS Lima… - Microbiology …, 2023 - Am Soc Microbiol
Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been
associated with physiological alterations that provide insights into the pathogenesis of the …

Single-cell RNA sequencing analysis of the immunometabolic rewiring and immunopathogenesis of coronavirus disease 2019

F Qi, W Zhang, J Huang, L Fu, J Zhao - Frontiers in Immunology, 2021 - frontiersin.org
Although immune dysfunction is a key feature of coronavirus disease 2019 (COVID-19), the
metabolism-related mechanisms remain elusive. Here, by reanalyzing single-cell RNA …

Metabolic and immune markers for precise monitoring of COVID-19 severity and treatment

AF Rendeiro, CK Vorkas, J Krumsiek… - Frontiers in …, 2022 - frontiersin.org
Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount
for the discovery of early biomarkers of outcome of coronavirus disease 2019 (COVID-19) …