The large chromosomal deletions frequently observed in cancer genomes are often thought
to arise as a “two-hit” mechanism in the process of tumor-suppressor gene (TSG) …

Homozygous deletions of recessive cancer genes and fragile sites are known to occur in
human cancers. We identified 281 homozygous deletions in 636 cancer cell lines. Of these …

High frequency of chromosomal deletions elicited as losses of heterozygosity is a hallmark
of genomic instability in cancer. Functional losses of tumor suppressor genes caused by loss …

Classical tumour suppressor genes are thought to require mutation or loss of both alleles to
facilitate tumour progression. However, it has become clear over the last few years that for …

To identify the location of one or more of the putative tumor suppressor genes (TSG) on
chromosome arm 4q that may be involved in hepatocellular carcinoma (HCC), we examined …

Publisher Summary Genomic changes of all kinds, ranging from base substitutions,
deletions, duplications, amplifications, and rearrangements, are characteristic of malignant …

We used overlapping and nested homozygous deletions, contig building, genomic
sequencing, and physical and transcript mapping to further define a∼ 630-kb lung cancer …

Cancer cells silence autosomal tumor suppressor genes by Knudson's two-hit mechanism in
which loss-of-function mutations and then loss of heterozygosity occur at the tumor …

Human chromosome 8p23 is known as a region that is associated with loss of
heterozygosity (LOH), which is frequently deleted in hepatocellular carcinoma (HCC) …

The pathogenic role for heritable mutations in the DNA sequence of tumor suppressor and
DNA repair genes has been well established in familial cancer syndromes. These germ line …