Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

J Heuberger, J Trimpert, D Vladimirova… - EMBO molecular …, 2021 - embopress.org
Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including
those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme …

[PDF][PDF] Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells

ML Stanifer, C Kee, M Cortese, CM Zumaran, S Triana… - Cell reports, 2020 - cell.com
Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an
unprecedented worldwide health problem that requires concerted and global approaches to …

SARS-CoV-2 productively infects human gut enterocytes

MM Lamers, J Beumer, J van der Vaart, K Knoops… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the …

[HTML][HTML] SARS-CoV-2 infection: host response, immunity, and therapeutic targets

P Shivshankar, H Karmouty-Quintana, T Mills… - Inflammation, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global pandemic with …

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer

H Shuai, H Chu, Y Hou, D Yang, Y Wang, B Hu… - Journal of Infection, 2020 - Elsevier
Objectives Respiratory and intestinal tract are two primary target organs of SARS-CoV-2
infection. However, detailed characterization of the host-virus interplay in infected human …

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut

S Triana, C Metz‐Zumaran, C Ramirez… - Molecular systems …, 2021 - embopress.org
Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology.
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little …

[HTML][HTML] Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome

ST Koester, N Li, DM Lachance, NM Morella, N Dey - Plos one, 2021 - journals.plos.org
COVID-19 (coronavirus disease 2019) patients exhibiting gastrointestinal symptoms are
reported to have worse prognosis. Ace2 (angiotensin-converting enzyme 2), the gene …

[HTML][HTML] Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection

KK Jang, ME Kaczmarek, S Dallari, YH Chen… - PLoS …, 2022 - journals.plos.org
Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly
variable for reasons that are not understood. In this study, we used intestinal organoid …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection

T Duan, C Xing, J Chu, X Deng, Y Du, X Liu, Y Hu… - Nature Cell …, 2024 - nature.com
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …