Apigenin ameliorates di (2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake

D Han, Y Yao, L Chen, Z Miao, S Xu - Food and Chemical Toxicology, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant,
the contamination of which infiltrates daily human life from many aspects, imperceptibly …

Potential role of lycopene in the inhibition of di (2-ethylhexyl) phthalate-induced ferroptosis in spleen via modulation of iron ion homeostasis

XY Dai, SY Zhu, MZ Li, M Talukder… - ACS Pharmacology & …, 2021 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is a synthetic chemical and widely used as a plasticizer.
Humans can be exposed to DEHP through direct contact or environmental contamination …

Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice

F Zhang, H Zhen, H Cheng, F Hu, Y Jia… - Frontiers in Cell and …, 2022 - frontiersin.org
As one kind of endocrine disrupting chemical, di-(2-ethylhexyl) phthalate (DEHP) has been
reported to cause liver dysfunction in epidemiological and experimental studies. Abnormal …

Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis

JX Wang, Y Zhao, MS Chen, H Zhang, JG Cui… - Environmental Pollution, 2023 - Elsevier
Phthalates as a large group of environmental pollutants are used primarily as plasticizers
and solvents, which have become a growing problem worldwide. Epidemiological results …

Novel role of hemeoxygenase-1 in phthalate-induced renal proximal tubule cell ferroptosis

MS Chen, JX Wang, H Zhang, JG Cui… - Journal of Agricultural …, 2023 - ACS Publications
Phthalates are widely used to improve the flexibility of poly (vinyl chloride)(PVC) polymer
agriculture products. Di (2-ethylhexyl) phthalate (DEHP) is a type of addition to plastic and …

Di (2‐ethylhexyl) phthalate‐induced apoptosis in rat INS‐1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection

X Sun, Y Lin, Q Huang, J Shi, L Qiu… - Journal of cellular …, 2015 - Wiley Online Library
Abstract Di (2‐ethylhexyl) phthalate (DEHP) is used as plasticizer and is ubiquitously found
in the environment. Exposure to DEHP has been linked to an increased incidence of type 2 …

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

N Yamada, T Karasawa, H Kimura, S Watanabe… - Cell death & …, 2020 - nature.com
Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure.
Although hepatocyte cell death is considered to be the critical event in APAP-induced …

Role of ferroptosis in acetaminophen-induced hepatotoxicity

N Yamada, T Karasawa, M Takahashi - Archives of Toxicology, 2020 - Springer
We read with great interest the review article by which Jaeschke et al.(2019) in which the
authors thoroughly reviewed the forms of cell death in acetaminophen (APAP)-induced …

Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes

Y Wu, J Wang, T Zhao, J Chen, L Kang, Y Wei… - Journal of hazardous …, 2022 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is an extensively used plasticizer and has been
shown to cause reproductive dysfunction in humans and model animals. However, the exact …

Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells

T Hou, X Fan, Q Zhang, H Zhang, D Zhang, L Tao… - Environmental …, 2024 - Elsevier
Dibutyl phthalate (DBP) contamination has raised global concern for decades, while its
health risk with toxic mechanisms requires further elaboration. This study used zebrafish ZF4 …