[HTML][HTML] Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients

PC Teixeira, GP Dorneles, PC Santana Filho… - International …, 2021 - Elsevier
Mucosal barrier alterations may play a role in the pathogenesis of several diseases,
including COVID-19. In this study we evaluate the association between bacterial …

Association between the expression of toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity

W Alturaiki, H Alkadi, S Alamri, ME Awadalla, A Alfaez… - Heliyon, 2023 - cell.com
The recent identification of the involvement of the immune system response in the severity
and mortality of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection highlights …

Increased inflammatory mediators levels are associated with clinical outcomes and prolonged illness in severe COVID-19 patients

W Hao, M Liu, C Bai, X Liu, S Niu, X Chen - International …, 2023 - Elsevier
Objective The purpose of this study was to identify potential predictors of clinical outcome in
severe COVID-19 patients and to investigate the relationship between immunological …

Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients

GP Dorneles, PC Teixeira, A Peres… - Journal of Molecular …, 2023 - Springer
Higher endotoxin in the circulation may indicate a compromised state of host immune
response against coinfections in severe COVID-19 patients. We evaluated the inflammatory …

Immunological and inflammatory profiles during acute and convalescent phases of severe/critically ill COVID-19 patients

Q Chen, B Yu, Y Yang, J Huang, Y Liang, J Zhou… - International …, 2021 - Elsevier
Abstract Background The 2019 Coronavirus (COVID-19) pandemic poses a huge threat
internationally; however, the role of the host immune system in the pathogenesis of COVID …

Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID

NA Scott, L Pearmain, SB Knight… - European …, 2023 - Eur Respiratory Soc
Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …

Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19

R Kahn, T Schmidt, K Golestani… - Journal of Leucocyte …, 2021 - academic.oup.com
The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and
high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases …

Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study

A Tufa, TH Gebremariam, T Manyazewal… - Frontiers in …, 2022 - frontiersin.org
Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may
represent disease severity. We aimed to assess plasma inflammatory mediator …

Comparative study of the lymphocyte change between COVID-19 and non-COVID-19 pneumonia cases suggesting uncontrolled inflammation might not be the main …

Y Zheng, Z Huang, G Yin, X Zhang, W Ye, Z Hu, C Hu… - Medrxiv, 2020 - medrxiv.org
Background The 2019 novel coronavirus (COVID-19) emerged in Wuhan in December 2019
and has since rapidly spread across China and to the globe. This virus shows unusually …

Immunoglobulin G immune complexes may contribute to neutrophil activation in the course of severe coronavirus disease 2019

I Mazzitelli, L Bleichmar, MG Ludueña… - The Journal of …, 2021 - academic.oup.com
Abstract Severe coronavirus disease 2019 (COVID-19) is associated with an overactive
inflammatory response mediated by macrophages. Here, we analyzed the phenotype and …