The development of small molecules targeting methyltransferase-like 3

H Li, Q Zhang, Q Feng, Q You, X Guo - Drug Discovery Today, 2023 - Elsevier
Abstract In mammals, N 6-methyladenosine (m 6 A) is thought to be the most common and
conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of …

New insights into the regulation of METTL3 and its role in tumors

Q Jin, H Qu, C Quan - Cell Communication and Signaling, 2023 - Springer
As one of the most abundant epigenetic modifications in RNA, N6-methyladenosine (m6A)
affects RNA transcription, splicing, stability, and posttranscriptional translation …

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …

Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation

M Pomaville, M Chennakesavalu, P Wang, Z Jiang… - Cell reports, 2024 - cell.com
Summary The N 6-methyladenosine (m 6 A) RNA modification is an important regulator of
gene expression. m 6 A is deposited by a methyltransferase complex that includes …

Discovery of METTL3 small molecule inhibitors by virtual screening of natural products

Y Du, Y Yuan, L Xu, F Zhao, W Wang, Y Xu… - Frontiers in …, 2022 - frontiersin.org
N6-Methyladenosine (m6A) is the most prevalent mRNA modification in mammalian cells
that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and …

[HTML][HTML] METTL3 plays multiple functions in biological processes

S Liu, L Zhuo, J Wang, Q Zhang, Q Li, G Li… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification of mRNAs
in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like …

Mining for METTL3 inhibitors to suppress cancer

J Li, RI Gregory - Nature structural & molecular biology, 2021 - nature.com
The RNA methyltransferase METTL3 catalyzes N 6-methyladenosine (m6A) modification of
messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute …

Novel insights into the m6A-RNA methyltransferase METTL3 in cancer

Y Cai, R Feng, T Lu, X Chen, X Zhou, X Wang - Biomarker Research, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is a prevalent internal RNA modification in higher
eukaryotic cells. As the pivotal m 6 A regulator, RNA methyltransferase-like 3 (METTL3) is …

Multifaceted Roles of the N6-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment

C Hu, J Liu, Y Li, W Jiang, D Ji, W Liu, T Ma - Biomolecules, 2022 - mdpi.com
As the most abundant internal mRNA modification in eukaryotic cells, N 6-methyladenosine
(m6A) has emerged as an important regulator of gene expression and has a profound …

METTL3 from target validation to the first small-molecule inhibitors: a medicinal chemistry journey

F Fiorentino, M Menna, D Rotili… - Journal of Medicinal …, 2023 - ACS Publications
RNA methylation is a critical mechanism for regulating the transcription and translation of
specific sequences or for eliminating unnecessary sequences during RNA maturation …