Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
EP Tissink, AA Shadrin, D van der Meer… - Nature …, 2024 - nature.com
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from
one neuroimaging modality (eg structural, functional or diffusion magnetic resonance …
one neuroimaging modality (eg structural, functional or diffusion magnetic resonance …
Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from
one neuroimaging modality (eg structural, functional or diffusion MRI). A better …
one neuroimaging modality (eg structural, functional or diffusion MRI). A better …
Beyond heritability: improving discoverability in imaging genetics
Structural neuroimaging measures based on magnetic resonance imaging have been at the
forefront of imaging genetics. Global efforts to ensure homogeneity of measurements across …
forefront of imaging genetics. Global efforts to ensure homogeneity of measurements across …
Large-scale genomics unveil polygenic architecture of human cortical surface area
Little is known about how genetic variation contributes to neuroanatomical variability, and
whether particular genomic regions comprising genes or evolutionarily conserved elements …
whether particular genomic regions comprising genes or evolutionarily conserved elements …
The genetic basis of human brain structure and function: 1,262 genome-wide associations found from 3,144 GWAS of multimodal brain imaging phenotypes from …
The genetic basis of brain structure and function is largely unknown. We carried out genome-
wide association studies (GWAS) of 3,144 distinct functional and structural brain imaging …
wide association studies (GWAS) of 3,144 distinct functional and structural brain imaging …
Polygenic architecture of human neuroanatomical diversity
We analyzed the genomic architecture of neuroanatomical diversity using magnetic
resonance imaging and single nucleotide polymorphism (SNP) data from> 26 000 …
resonance imaging and single nucleotide polymorphism (SNP) data from> 26 000 …
[HTML][HTML] Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture
Genetic contributions to human cortical structure manifest pervasive pleiotropy. This
pleiotropy may be harnessed to identify unique genetically-informed parcellations of the …
pleiotropy may be harnessed to identify unique genetically-informed parcellations of the …
Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions
Pleiotropy occurs when a genetic variant influences more than one trait. This is a key
property of the genomic architecture of psychiatric disorders and has been observed for rare …
property of the genomic architecture of psychiatric disorders and has been observed for rare …
Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis
Recent work in imaging genetics suggests high levels of genetic overlap within cortical
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …
Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components
The heritability of cortical brain imaging phenotypes has been a subject of investigation for
several years. Prior studies have employed both twin datasets and genome-wide …
several years. Prior studies have employed both twin datasets and genome-wide …