Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …

The molecular mechanisms underlying cancer immune escape are a core topic in cancer
immunology research. Cancer cells can escape T cell-mediated cellular cytotoxicity by …

Evasion of immune system is a hallmark of cancer, which enables cancer cells to escape the
attack from immune cells. Cancer cells can express many immune inhibitory signalling …

PD-L1, frequently expressed in human cancers, engages with PD-1 on immune cells and
contributes to cancer immune evasion. As such, antibodies blocking the PD-1/PD-L1 …

The immunosuppressive molecule programmed death-ligand 1 (PD-L1) is frequently
upregulated in human cancers. Binding of PD-L1 to its receptor, programmed death-1 (PD …

Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …

Although targeting programmed death 1/programmed death ligand 1 (PD-1/PD-L1) has
achieved durable responses and disease remission in patients with certain cancers …

The membrane-bound molecules programmed death 1 (PD-1) and its ligand PD-L1 (PD-
1/PD-L1) belong to the immune checkpoint pathway. PD-1 pathway downregulates effector …

Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in
the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain …

Cancer immunotherapy has been accompanied by promising results over the past few
years. Programmed Cell Death Protein 1 (PD-1) plays a vital role in inhibiting immune …