RNA and DNA modifications occur in eukaryotes and prokaryotes, as well as in their viruses,
and serve a wide range of functions, from gene regulation to nucleic acid protection …

RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by
standard detection methods of molecular biology and cell biology. With a burst of knowledge …

Motivation The chemical modification of ribonucleotides regulates the structure, stability and
interactions of RNAs. Profiling of these modifications using short-read (Illumina) sequencing …

Modified nucleotides in mRNA are an essential addition to the standard genetic code of four
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …

Dynamic shifts between open reading frames and the redefinition of codon meaning at
specific sites, programmed by signals in mRNA, permits versatility of gene expression. Such …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

Rapid characterization of unknown biological samples is under the focus of many current
studies. Here we report a method for screening of biological samples by optical mapping of …

Advances in nanopore sequencing technology have enabled investigation of the full
catalogue of covalent DNA modifications. We present the first algorithm for the identification …

A computational strategy for determining the variability of long DNA sequences in microbial
genomes is described. Composite portraits of bacterial genomes were obtained by …

Genome modifications are central components of the continuous arms race between viruses
and their hosts. The archaeosine base (G+), which was thought to be found only in archaeal …