A randomized double-blind placebo-controlled clinical trial of nitazoxanide for treatment of mild or moderate COVID-19

JF Rossignol, MC Bardin, J Fulgencio… - …, 2022 - thelancet.com
Background There is an urgent need for treatments of mild or moderate COVID-19 in an
outpatient setting. Methods A randomized double-blind placebo-controlled clinical trial in 36 …

Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial

PRM Rocco, PL Silva, FF Cruz… - European …, 2021 - Eur Respiratory Soc
Background Nitazoxanide is widely available and exerts broad-spectrum antiviral activity in
vitro. However, there is no evidence of its impact on severe acute respiratory syndrome …

[HTML][HTML] Nitazoxanide superiority to placebo to treat moderate COVID-19–A Pilot prove of concept randomized double-blind clinical trial.

VF Blum, S Cimerman, JR Hunter, P Tierno… - …, 2021 - thelancet.com
Background The absence of specific antivirals to treat COVID-19 leads to the repositioning
of candidates' drugs. Nitazoxanide (NTZ) has a broad antiviral effect. Methods This was a …

Efficacy of Nitazoxanide in reducing the viral load in COVID-19 patients. Randomized, placebo-controlled, single-blinded, parallel group, pilot study.

M Silva, A Espejo, ML Pereyra, M Lynch, M Thompson… - Medrxiv, 2021 - medrxiv.org
The fast spread of COVID-19 has overcrowded Public Health Systems facilities in major
countries due to the large number of seriously ill patients, particularly those requiring …

[HTML][HTML] Review of safety and minimum pricing of nitazoxanide for potential treatment of COVID-19

T Pepperrell, V Pilkington, A Owen, J Wang… - Journal of virus …, 2020 - Elsevier
Background Many treatments are being assessed for repurposing to treat coronavirus
disease 2019 (COVID-19). One drug that has shown promising results in vitro is …

An open label, adaptive, phase 1 trial of high‐dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS‐CoV‐2

LE Walker, R FitzGerald, G Saunders… - Clinical …, 2022 - Wiley Online Library
Repurposing approved drugs may rapidly establish effective interventions during a public
health crisis. This has yielded immunomodulatory treatments for severe coronavirus disease …

Nitazoxanide in patients hospitalized with COVID-19 pneumonia: a multicentre, randomized, double-blind, placebo-controlled trial

PRM Rocco, PL Silva, FF Cruz, PF Tierno… - Frontiers in …, 2022 - frontiersin.org
Background Nitazoxanide exerts antiviral activity in vitro and in vivo and anti-inflammatory
effects, but its impact on patients hospitalized with COVID-19 pneumonia is uncertain …

Nitazoxanide against COVID-19 in three explorative scenarios

JM Calderón, MRF Flores, LP Coria… - The Journal of Infection …, 2020 - jidc.org
Introduction: Nitazoxanide has shown efficacy in vitro against coronavirus infections (MERS,
SARS, SARS-CoV-2). The aim of this report is to describe the results of treating COVID-19 …

Potential role for nitazoxanide in treating SARS-CoV-2 infection

PR Martins-Filho, JA Barreto-Alves… - American Journal of …, 2020 - journals.physiology.org
TO THE EDITOR: Until specific and effective antiviral therapies against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) become available, the management of …

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis

RKR Rajoli, H Pertinez, U Arshad, H Box… - British Journal of …, 2021 - Wiley Online Library
Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been
declared a global pandemic and urgent treatment and prevention strategies are needed …