Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-
autonomous program but as a multifaceted and complex series of events, which is …

Metastases represent the end products of a multistep cell-biological process termed the
invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically …

The clinical manifestation of metastasis in a vital organ is the final stage of cancer
progression and the main culprit of cancer-related mortality. Once established, metastasis is …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Metastases are responsible for the vast majority of cancer-related deaths, but, despite
intense efforts to understand their underlying mechanisms with the goal of uncovering …

Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …