COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the" Spike effect"

F Angeli, G Reboldi, M Trapasso, M Zappa… - European journal of …, 2022 - Elsevier
The role of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19
is well recognized. The imbalance between angiotensin II (Ang II) and Angiotensin 1-7 (Ang …

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
Abstract Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell
of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are …

Rethinking the role of the renin-angiotensin system in the pandemic era of SARS-CoV-2

F Angeli, M Zappa, P Verdecchia - Journal of cardiovascular …, 2023 - mdpi.com
After assessing the levels of spread and severity of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, academic literature focused on the pathophysiology …

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection: one year later

F Angeli, M Zappa, G Reboldi, M Trapasso… - European journal of …, 2021 - Elsevier
The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) generated much interest on the basic pathogenetic mechanisms through which SARS …

Effects of SARS-CoV-2 on cardiovascular system: the dual role of angiotensin-converting enzyme 2 (ACE2) as the virus receptor and homeostasis regulator-review

A Aleksova, G Gagno, G Sinagra, AP Beltrami… - International journal of …, 2021 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID …

COVID-19, ACE2, and the cardiovascular consequences

AM South, DI Diz, MC Chappell - American Journal of …, 2020 - journals.physiology.org
The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to
patients with underlying cardiovascular disease (CVD). The mechanism for SARS-CoV-2 …

Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System: JACC Review Topic of the Week

A Brojakowska, J Narula, R Shimony… - Journal of the American …, 2020 - jacc.org
Severe acute respiratory-syndrome coronavirus-2 (SARS-CoV-2) host cell infection is
mediated by binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation …

Downregulation of ACE2 induces overstimulation of the renin–angiotensin system in COVID-19: should we block the renin–angiotensin system?

F Silhol, G Sarlon, JC Deharo, B Vaïsse - Hypertension Research, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 is the cause of the ongoing coronavirus
disease-19 (COVID-19) pandemic. Mortality is mainly due to acute respiratory distress …

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19

JR Cook, J Ausiello - Reviews in Endocrine and Metabolic Disorders, 2022 - Springer
Abstract SARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting
enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter …

Binding of SARS-CoV-2 and angiotensin-converting enzyme 2: clinical implications

E Murray, M Tomaszewski, TJ Guzik - Cardiovascular Research, 2020 - academic.oup.com
The emergence and consequent impact of COVID-19 has led to clinicians and academics
looking for evidence, with clinical controversies to parallel socio-economical and political …