Highlights•Resting-state fMRI biomarkers in psychiatry often lack disorder specificity.•
Transdiagnostic study designs allow direct assessment of biomarker specificity.•p-factor …

A main goal in translational neuroscience is to identify neural correlates of psychopathology
(“biomarkers”) that can be used to facilitate diagnosis, prognosis, and treatment. This goal …

Functional neuroimaging has made fundamental contributions to our understanding of brain
function. It remains challenging, however, to translate these advances into diagnostic tools …

Abstract Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise
to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such …

Central to the development of clinical applications of functional connectomics for neurology
and psychiatry is the discovery and validation of biomarkers. Resting state fMRI (R-fMRI) is …

Translational neuroscience is an important field that brings together clinical praxis with
neuroscience methods. In this review article, the focus will be on functional neuroimaging …

Medication and other therapies for psychiatric disorders show unsatisfying efficacy, in part
due to the significant clinical/biological heterogeneity within each disorder and our over …

Human behavior comprises many aspects that stand out by their dynamic nature. To quantify
its neural underpinnings, time-resolved fMRI methods have blossomed over the past …

Difficulties with higher-order cognitive functions in youth are a potentially important
vulnerability factor for the emergence of problematic behaviors and a range of …

Functional connectomes reveal biomarkers of individual psychological or clinical traits.
However, there is great variability in the analytic pipelines typically used to derive them from …