Cells from some tumors use an altered metabolic pattern compared with that of normal
differentiated adult cells in the body. Tumor cells take up much more glucose and mainly …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells'
energy generation is different from that of normal cells. They observed high glucose …

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative
phosphorylation to generate the energy needed for cellular processes, most cancer cells …

Abstract In the 1920s, Otto Warburg observed that tumor cells consumed a large amount of
glucose, much more than normal cells, and converted most of it to lactic acid. This …

Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …

Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic
phenotype of cancer is aerobic glycloysis–also known as the Warburg effect–characterized …

Abstract In 1927, Otto Warburg and coworkers reported the increased uptake of glucose and
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …

Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …

In differentiated normal cells, the conventional route of glucose metabolism involves
glycolysis, followed by the citric acid cycle and electron transport chain to generate usable …