Objectives The worldwide emergence of antibiotic resistance calls for effective exploitation
of existing antibiotics. Antibiotic combinations with different modes of action can synergize …

Objectives To evaluate the activity of meropenem–amikacin and meropenem–colistin
combinations with checkerboard broth microdilution (CKBM) compared with isothermal …

Background Synergistic combination antimicrobial therapy may provide new options for
treatment of MDR infections. However, comprehensive in vitro synergy data are limited and …

Objectives Increased rates of carbapenem-resistant strains of Acinetobacter baumannii have
forced clinicians to rely upon last-line agents, such as the polymyxins, or empirical …

Objectives Precise assessment of potential therapeutic synergy, antagonism or indifference
between antimicrobial agents currently depends on time-consuming and hard-to …

Background: Because of the rapid spread of antimicrobial resistance and the slow
development of novel antimicrobials, Gram-negative infections treatments are challenging …

Objectives To evaluate the performance of an isothermal microcalorimetry (IMC) method for
determining the MICs among extensively drug-resistant Gram-negative bacilli. Methods A …

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE), especially for
carbapenemase-producing Enterobacteriaceae (CPE), is an emerging cause that pose a …

The objective of this study was to determine the comparative pharmacodynamics of four
different carbapenems in combination with polymyxin B (PMB) against carbapenem …

Polymyxins are commonly used as the last resort for the treatment of MDR Acinetobacter
baumannii and Klebsiella pneumoniae nosocomial infections; however, apart from the …