Current structural knowledge on the CNNM family of magnesium transport mediators
P Giménez-Mascarell, I González-Recio… - International Journal of …, 2019 - mdpi.com
The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators,
CNNMs, are key players in maintaining the homeostasis of magnesium in different organs …
CNNMs, are key players in maintaining the homeostasis of magnesium in different organs …
Structural insights into the intracellular region of the human magnesium transport mediator CNNM4
P Giménez-Mascarell, I Oyenarte… - International Journal of …, 2019 - mdpi.com
The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent
metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium …
metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium …
New insights into the structure and function of CNNM proteins
Magnesium (Mg2+) is the most abundant divalent cation in cells and plays key roles in
almost all biological processes. CBS‐pair domain divalent metal cation transport mediators …
almost all biological processes. CBS‐pair domain divalent metal cation transport mediators …
Molecular function and biological importance of CNNM family Mg2+ transporters
Cyclin M (CNNM) family proteins are evolutionarily conserved Mg2+ transporters. They
extrude Mg2+ from cells and maintain intracellular Mg2+ levels within the normal range …
extrude Mg2+ from cells and maintain intracellular Mg2+ levels within the normal range …
Structural and functional comparison of magnesium transporters throughout evolution
GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter
Ancient conserved domain protein/cyclin M (CNNM) family proteins are evolutionarily
conserved Mg 2+ transporters. However, their biochemical mechanism of action remains …
conserved Mg 2+ transporters. However, their biochemical mechanism of action remains …
Mg2+-ATP sensing in CNNM, a putative magnesium transporter
The family of cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport
mediators (CNNMs) is composed of four integral membrane proteins associated with Mg 2+ …
mediators (CNNMs) is composed of four integral membrane proteins associated with Mg 2+ …
[HTML][HTML] The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity
Proteins of the cyclin M family (CNNMs; also called ancient conserved domain proteins, or
ACDPs) are represented by four integral membrane proteins that have been proposed to …
ACDPs) are represented by four integral membrane proteins that have been proposed to …
Mg2+ Transporters in Digestive Cancers
J Auwercx, P Rybarczyk, P Kischel, I Dhennin-Duthille… - Nutrients, 2021 - mdpi.com
Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its
role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is …
role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is …
Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter
The CNNM/CorC family proteins are Mg2+ transporters that are widely distributed in all
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …