The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

The genetic basis of major depression

KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

DF Levinson, S Mostafavi… - Biological …, 2014 - biologicalpsychiatryjournal.com
Over the past 5 years, the genome-wide association study (GWAS) method has produced
significant findings that are providing insights into the biological pathways involved in …

Poor replication of candidate genes for major depressive disorder using genome-wide association data

FJ Bosker, CA Hartman, IM Nolte, BP Prins… - Molecular …, 2011 - nature.com
Abstract Data from the Genetic Association Information Network (GAIN) genome-wide
association study (GWAS) in major depressive disorder (MDD) were used to explore …

[HTML][HTML] A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of … - Molecular …, 2013 - ncbi.nlm.nih.gov
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

Uncovering the genetic architecture of major depression

AM McIntosh, PF Sullivan, CM Lewis - Neuron, 2019 - cell.com
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …

The genetics of depression: successful genome-wide association studies introduce new challenges

J Ormel, CA Hartman, H Snieder - Translational psychiatry, 2019 - nature.com
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …

Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings

M Kamran, F Bibi, A ur. Rehman, DW Morris - Genes, 2022 - mdpi.com
Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Overview of the genetics of major depressive disorder

FW Lohoff - Current psychiatry reports, 2010 - Springer
Major depressive disorder (MDD) is a common psychiatric illness with high levels of
morbidity and mortality. Despite intensive research during the past several decades, the …