Multi‐Omics Studies in Historically Excluded Populations: The Road to Equity
Over the past few decades, genomewide association studies (GWASs) have identified the
specific genetics variants contributing to many complex diseases by testing millions of …
specific genetics variants contributing to many complex diseases by testing millions of …
[HTML][HTML] The importance of diversity in precision medicine research
Personalized or precision medicine is meant to distinguish tailored treatment from trial and
error. The contemporary concept has evolved to specifically include the 'omic profile of a …
error. The contemporary concept has evolved to specifically include the 'omic profile of a …
Diversity in precision medicine and pharmacogenetics: methodological and conceptual considerations for broadening participation
AB Popejoy - Pharmacogenomics and Personalized Medicine, 2019 - Taylor & Francis
Genome-wide association studies (GWAS) have revealed important links between genetic
markers across the human genome and phenotypic traits, including risk factors for disease …
markers across the human genome and phenotypic traits, including risk factors for disease …
Harnessing the power of electronic health records and genomics for drug discovery
K Krebs, L Milani - Annual Review of Pharmacology and …, 2023 - annualreviews.org
A long-standing recognition that information from human genetics studies has the potential
to accelerate drug discovery has led to decades of research on how to leverage genetic and …
to accelerate drug discovery has led to decades of research on how to leverage genetic and …
The page study: how genetic diversity improves our understanding of the architecture of complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development, and clinical guidelines. However, the …
the biology of complex traits, drug development, and clinical guidelines. However, the …
Personalized medicine: temper expectations
DW Nebert, G Zhang - Science, 2012 - science.org
THE 1 JUNE POLICY FORUMS,“THE ULTIMATE GENETIC TEST”(R. DRMANAC, P. 1110)
AND “Whole-genome sequencing: The new standard of care?”(LR Brunham and MR …
AND “Whole-genome sequencing: The new standard of care?”(LR Brunham and MR …
Integration of real‐world data and genetics to support target identification and validation
JM Davitte, M Stott‐Miller, MG Ehm… - Clinical …, 2022 - Wiley Online Library
Even modest improvements in the probability of success of selecting drug targets which are
ultimately approved can substantially reduce the costs of research and development. Drug …
ultimately approved can substantially reduce the costs of research and development. Drug …
Genome-wide association studies: results from the first few years and potential implications for clinical medicine
JN Hirschhorn, ZKZ Gajdos - Annual review of medicine, 2011 - annualreviews.org
Most common diseases and quantitative traits are heritable: determined in part by genetic
variation within the population. The inheritance is typically polygenic in that combined effects …
variation within the population. The inheritance is typically polygenic in that combined effects …
[HTML][HTML] Multi-Omics Study in Revealing Underlying Pathogenesis of Complex Diseases: A Translational Perspective
Genetics contributes to our understanding of the development of complex diseases. In the
past few years, a large number of disease-associated loci have been identified using …
past few years, a large number of disease-associated loci have been identified using …
Multi-omics study for interpretation of genome-wide association study
M Akiyama - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with complex traits, including a wide variety of diseases. Despite the successful …
associated with complex traits, including a wide variety of diseases. Despite the successful …