Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

During the past century, treatments for the diseases of youth and middle age have helped
raise life expectancy significantly. However, cognitive decline has emerged as one of the …

[illus. 1] The prevalence of neurodegenerative disorders is increasing, owing--in part--to
extensions in lifespan. Currently, there is no cure for any of these diseases, although not for …

Advances in our knowledge of age-associated diseases have far outpaced advances in our
understanding of the fundamental ageing processes that underlie the vulnerability to these …

In the central nervous system, ageing results in a precipitous decline in adult neural
stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive …

Recent discoveries in the science of ageing indicate that lifespan in model organisms such
as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional …

Greek para, meaning 'alongside', and bios, meaning 'life'.) It mimics natural instances of
shared blood supply, such as in conjoined twins or animals that share a placenta in the …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

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We all know that age-related neurodegenerative diseases affect aging individuals. So why
does basic research continue to make use of the immature nervous system or mutants that …