Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Summary Coronavirus disease 2019 (COVID‐19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and has resulted in more than 6 million deaths …

Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

SARS-CoV-2 infection results in a spectrum of outcomes from no symptoms to widely
varying degrees of illness to death. A better understanding of the immune response to SARS …

Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …

Background Increased inflammation is a hallmark of COVID-19, with pulmonary and
systemic inflammation identified in multiple cohorts of patients. Definitive cellular and …

The Coronavirus Disease 2019 (COVID-19) is caused by the betacoronavirus Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus that can mediate asymptomatic or …

Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute …